Cisplatin pten
WebObjective: Resistance to cisplatin-centered chemotherapy is a major cause of treatment failure in human ovarian cancer. Whereas PTEN, a tumor suppressor gene product, is believed to promote apoptosis primarily via inactivation of the PI3K/Akt cell survival pathway, recent evidence suggests that PTEN may function independently of this pathway. WebNov 19, 2024 · Cisplatin is an anti-cancer chemotherapy drug which used to treat ovarian cancer in women who have already received surgery and/or radiation treatment. …
Cisplatin pten
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WebMay 10, 2013 · Cisplatin treatment promotes phosphorylation of AKT. PTEN is known as a negative regulator of AKT phosphorylation. The phosphorylation of AKT was analyzed … WebJan 12, 2024 · Cervical cancer is one of the most common female malignancies, and cisplatin-based chemotherapy is routinely utilized in locally advanced cervical cancer patients. However, resistance has been the major limitation. In this study, we found that Na+/H+ Exchanger Regulatory Factor 1 (NHERF1) was downregulated in cisplatin …
WebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is often … WebSep 24, 2024 · The main lipid substrate of PTEN is PIP 3 and indeed PTEN acts as a negative regulator of PI3K/AKT signaling. ... Wu, D. M. et al. The PAX6-ZEB2 axis promotes metastasis and cisplatin resistance ...
WebThis is the case of vesicular miR-21 that induced cisplatin resistance in oral squamous cell carcinoma by targeting phosphatase and tensin homolog (PTEN) and programmed cell death protein 4 (PDCD4), which are tumor suppressors involved in apoptosis, cell transformation, invasion, and tumor progression . WebJul 5, 2024 · Another in vivo study showed a synergistic effect of Cisplatin used in combination with the CK2-targeting compound CIGB-300, in nude mice xenografted with human cervical tumor cells, and an increased mice survival compared to single-agent treatment was observed [].The rationale of targeting CK2 in combination with Cisplatin …
WebDec 14, 2015 · Cisplatin is a first-line chemotherapeutic agent for ovarian cancer that acts by promoting DNA cross links and adduct. However drug resistance and considerable side effects including reproductive toxicity remain a significant challenge. PTEN is well known as a tumor suppressor function which plays a fundamental role in the regulation of the cell …
WebApr 5, 2013 · In addition, miR-21 induced cell survival and cisplatin resistance through downregulating the expression of phosphatase and tension homolog deleted on chromosome 10 (PTEN) and activation of Akt pathway. Inhibition of Akt using PI3K inhibitor LY 294002 could abrogate miR-21 induced cell survival. first shinwa helmet incWebNov 21, 2024 · PTEN-induced putative kinase 1 (PINK1)/Parkin-mediated mitophagy removes damaged mitochondria under various pathological conditions. The objective of this study was to determine mitophagy status and its effects on mitochondrial function and neuronal cell damage after cisplatin treatment using an in vitro model of cisplatin … camouflage waterproof jacketWebJun 18, 2015 · Drug resistance is a major cause of treatment failure in ovarian cancer patients, and novel therapeutic strategies are urgently needed. Overexpression of phosphatase and tensin homolog (PTEN) has been shown to preserve the cisplatin-resistance of ovarian cancer cells, while cisplatin-induced keratin 10 (KRT10) … camouflage websiteWebMay 10, 2024 · Although cisplatin (Cis) is an effective chemotherapeutic agent in treatment of various cancers, its adverse effect of nephrotoxicity limits the clinical application. Remote ischemic preconditioning (RIPC) is a strategy to induce resistance in a target organ against the oxidative stress and injury by applying transient, brief episodes of ischemia. first shinobi world warWebApr 10, 2024 · Indeed, PTEN serves as a dual-specific phosphatase that suppresses cell proliferation and induces apoptosis and cell cycle arrest via repressing PI3K/Akt signaling mechanisms [208]. Zheng et al. revealed that miR-24 increases the chemoresistance of human TSCC cell lines to cisplatin by downregulating PTEN [209]. camouflage webbingWebJun 7, 2024 · The PTEN gene was hypothesized to be regulated by miRNA-21 in ovarian cancer cisplatin resistance. Materials and methods Cell lines and cell culture The SKOV3 human ovarian cancer cell line was purchased from Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences (Shanghai, China). camouflage weber kettle coverWebBackground: Platinum-based chemotherapy, cisplatin (DDP) specifically, is the main strategy for treating lung cancer (LC). However, currently, there is a lack of predictive drug-resistance markers, and there is increased interest in the development of a reliable and sensitive panels of markers for DDP chemotherapy-effectiveness prediction. MicroRNAs … first ship homestuck