Diaphanous related formin 3
WebDiaphanous-related formin 3 (DIAPH3) has been reported to regulate the motility of cells by remodeling the cytoskeleton. However, the mechanism through which DIAPH3 … WebJul 30, 2024 · Analysis of the latter two hub modules revealed the following six hub genes: adhesion G protein-coupled receptor B3 (BAI3, also known as ADGRB3), cyclin F (CCNF), cytoskeleton-associated protein 2 like (CKAP2L), diaphanous-related formin 3 (DIAPH3), oxysterol binding protein-like 3 (OSBPL3), and RERG-like protein (RERGL).
Diaphanous related formin 3
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WebNov 1, 2024 · Abnormalities in nuclear shape are a well-known feature of cancer, but their contribution to malignant progression remains poorly understood. Here, we show that depletion of the cytoskeletal regulator, Diaphanous-related formin 3 (DIAPH3), or the nuclear membrane-associated proteins, lamin A/C, in prostate and breast cancer cells, … WebJul 1, 2024 · Diaphanous related formin 3 (DIAPH3) promotes tumorigenesis in hepatocellular carcinoma and lung adenocarcinoma, suggesting that DIAPH3 may be a …
WebIn this study, we identify diaphanous-related formin 3 (DIAPH3), an actin nucleator, as a scaffold protein to initiate liquid-liquid phase separation (LLPS) and form abundant … Webdiaphanous related formin 3 Synonyms 4930417P13Rik, Diap3, Drf3, mDia2, p134MDia2 Feature Type protein coding gene IDs MGI:1927222 NCBI Gene: 56419 Alliance gene …
WebOct 6, 2024 · Diaphanous-related formin 3 (DIAPH3) has been identified to play crucial roles in many malignant tumors. But its function and potential mechanism in CC remain largely unknown. In our study, DIAPH3 was frequently upregulated in CC tissue samples and increased expression of DIAPH3 was associated with poor overall survival according … WebStudies indicate that diaphanous related formin 1 (DIAPH1) is essentially involved in microtubules (MTs)-dependent early adhesion of colon cancer cells. A 51-year-old …
WebAug 5, 2024 · study demonstrated the oncogenic activity of DIAPH3 in the progression of hepatocellular carcinoma and suggested that PDIAPH3 might be a therapeutic target. …
WebDiaphanous-related formin 3 (DIAPH3) has been reported to regulate the motility of cells by remodeling the cytoskeleton. However, the mechanism through which DIAPH3 regulated the motility of cancer cells remains largely unknown. In this study, we have shown that the expression of DIAPH3 was up-regulated in HCC. grace lutheran church mcclusky ndWebDIAPH3 condensates formed by liquid-liquid phase separation act as a regulatory hub for stress-induced actin cytoskeleton remodeling Cell Rep. 2024 Jan 10;42 (1):111986. doi: 10.1016/j.celrep.2024.111986. Online ahead of print. Authors grace lutheran church marlin texasWebMar 29, 2024 · DIAPH3 diaphanous related formin 3 [ (human)] Gene ID: 81624, updated on 5-Feb-2024 Summary This gene encodes a member of the diaphanous subfamily of … chilling chardonnayWebHere we define a role for the Diaphanous-related formin-3 (DIAPH3) as a non-canonical regulator of metastasis that restrains conversion to amoeboid cell behaviour in multiple … grace lutheran church macungie paWebJan 28, 2011 · A similar intramolecular interaction between the DID and DAD also regulates the diaphanous-related formin mDia1, although, in this case, ... INF2_DID displays some specificity for mDia2_DAD, as it binds much more weakly to the DAD region of another diaphanous formin, FRL2 (Formin-like 3, FMNL3). We used point mutants in … chilling champagne in fridge timeWebJul 16, 2015 · Here, we show that loss of Diaphanous-related formin-3 (DIAPH3), frequently associated with metastatic breast and prostate cancers, correlates with increased sensitivity to taxanes. DIAPH3 interacted with microtubules (MT), and its loss altered several parameters of MT dynamics as well as decreased polarized force generation, … grace lutheran church mcpherson ksWebAug 19, 2024 · There is a diaphanous autoregulatory domain (DAD) in the C-terminal (Figure 1a); the DID domain binds to the DAD domain in a closed state, leading to an autoinhibited conformation of the formin . DRFs are mainly regulated by Rho GTPases that bind to GBD and DID domains and disrupt the autoregulatory complex [ 17 ] ( Figure 1 b). grace lutheran church marshfield wi