Gata3 and breast cancer

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August undefined, 2024

WebJun 1, 2009 · GATA3 expression inhibits breast tumor outgrowth and spontaneous lung metastasis. To test the hypothesis that GATA3 can negatively regulate the ability of … WebGATA3 in particular is necessary for mammary gland maturation, and its loss has been implicated in breast cancer development. Our goal was to validate the ability of GATA3 expression to predict survival in breast cancer patients. Protein expression of GATA3 was analyzed on a high-density tissue microarray consisting of 242 cases of breast cancer.

GATA-3 expression in breast cancer has a strong association with ...

WebMicroarray analysis of two normal and seven breast cancer samples found 129 genes with >fivefold changes. Further SAGE and EST analyses of these genes identified four … WebOct 25, 2024 · GATA3 regulates miR-455-3p transcription. To identify miRNAs that are potentially regulated by GATA3, we utilized GATA3-positive, noninvasive (MCF-7) breast cancer cells to define the miRNA expression profile with respect to this marker ().Morphologically, whereas control cells maintained organized cell-cell adhesion and … militiades shield

Cathepsin V suppresses GATA3 protein expression in luminal A …

WebNov 1, 2015 · GATA3 is a transcription factor regulating luminal cell differentiation in the mammary glands and has been implicated in the luminal types of breast carcinoma. The … WebTriple-negative breast cancer (TNBC) patients have an increased risk of developing visceral metastases and other primary nonbreast cancers, particularly lung cancer. ... GATA3 had moderate sensitivity (30.4%) and excellent specificity (98.7%) and misclassified only 2/152 LA (1.3%). GCDFP15 had a moderate sensitivity (20.8%) and excellent ... WebThe GATA3 expression was closely associated with tumor size as well as metastasis. GATA3 significantly suppressed OS cells proliferation, migration and invasion. EMT-associated transcript factor, slug, was transcriptionally inhibited by GATA3, thereby regulation of EMT in OS.Conclusion: GATA3 serves as a tumor suppressor in OS and … new york to mauritius

Role of GATA3 exon 6 germline mutations in breast cancer progression …

WebMar 4, 2024 · GATA3 acts as a suppressor in breast cancer metastasis, for it can mediate the reversal of epithelial-mesenchymal transition and thus promotes epithelial differentiation of invasive cancer cells [ 18, 19 ]. Further, GATA3 is also involved in the development of nervous system [ 20 ], kidney [ 21 ], and skin [ 22 ]. WebGATA3 is used predominantly to support the diagnosis of breast or urothelial origins in a carcinoma of unknown primary. GATA3 expression has been observed in 48–94% of breast carcinomas [1], [2], [3], [4]. In particular, the co-expression of CK7, GATA3, and ER is highly suggestive of breast cancer. new york to mcallenWeb14 GATA3 expression seems to be more extensive in lower grade tumors and positive cases, and cases with high expression may have a better survival 14,15 However, none of those studies have assessed the specificity of GATA3 for breast cancer. In another study, strong expression of GATA3 (in >50% tumor cells) was detected only in mammary (94% ... new york tombstone chinese

"Web21 hours ago · GATA3 is a transcription factor that is frequently mutated in breast cancers. Dr. Takaku’s group has developed a novel assay to investigate GATA3 functions and the mechanisms through which... " - Gata3 and breast cancer

Gata3 and breast cancer

Shift in GATA3 functions, and GATA3 mutations, control …

WebWhat is GATA3 positive breast cancer? GATA3 is a transcription factor closely associated with estrogen receptor alpha in breast carcinoma, with a potential prognostic utility. This study investigated the immunohistochemical expression of GATA3 in estrogen receptor alpha-positive and estrogen receptor alpha-negative breast carcinomas. WebThe GATA3 expression was closely associated with tumor size as well as metastasis. GATA3 significantly suppressed OS cells proliferation, migration and invasion. EMT …

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WebNov 20, 2014 · GATA binding protein 3 (GATA3) is a regulator of mammary luminal cell differentiation, and an estrogen receptor (ER) associated marker in breast cancer. … WebGATA3 can be particularly useful as a marker for metastatic breast carcinoma, especially triple-negative and metaplastic carcinomas, which lack specific markers …

WebNov 12, 2024 · GATA3 has been shown to be associated with the luminal subtype of breast cancer, whereas 88% of estrogen receptor (ER)-negative tumors retained GATA3 expression [ 15 ]. Its expression rate in triple-negative cancer ranged from 20.16 to 48% [ 16, 17] in contrast to 74.6% in apocrine type triple-negative breast cancer [ 18 ]. WebOct 25, 2024 · When combining GATA3, TRPS1, and MGP, we observed that 797/1201 (66.4%) of the enrolled breast carcinoma cases were positive for all three markers, including 452/565 (80.0%), 238/352 (67.6%), and 107/284 (37.7%) in the ER/PR+, HER2+, and TNBC subgroups, respectively (Table 3, Figs. 4 and 5 ).

WebJan 10, 2015 · TMAs were stained with SOX10, GATA3, GCDFP-15, and mammaglobin. Each stain was scored by the percent positive cells (0%, negative; <10%, focal; 10%-70%, patchy; >70%, diffuse) and intensity (weak, moderate or strong). >10% staining in tumor cells was considered positive. WebGATA3 in particular is necessary for mammary gland maturation, and its loss has been implicated in breast cancer development. Our goal was to validate the ability of GATA3 …

WebDec 15, 2005 · GATA binding protein 3 (GATA3), a transcriptional activator, emerged as one of the top genes with low expression in the meta-signature. In breast cancer, high GATA3 mRNA levels are seen in the luminal A …

Web21 hours ago · GATA3 is a transcription factor that is frequently mutated in breast cancers. Dr. Takaku’s group has developed a novel assay to investigate GATA3 functions and the … milith set genshinWebJul 1, 2024 · TRPS1, GATA3, and SOX10 expression (x10) in representative cases of triple-negative invasive breast carcinoma of no special type (IBC-NST). Case 1 shows a triple-negative IBC-NST with high expression of TRPS1 and GATA3 and negative expression of … new york to martha\u0027s vineyardWebSep 15, 2024 · We show that TET2 and FOXP1 form a chromatin complex that mediates demethylation of ESR1, GATA3, and FOXA1, three key genes that are known to coordinately orchestrate mammary luminal lineage... new york to mexico mapWebWe performed a survival analysis of 989 breast cancer patients from The Cancer Genome Atlas (TCGA), and validated the findings in 202 breast cancer patients from tissue microarray (TMA). Results In TCGA database, the mRNA expression of GATA3 and ZNF503 could not predict TNBC prognosis alone, though the ratio index, … new york to manchester uk flightsWebStudies have shown that GATA3 has a critical role in the development of epithelial structures in both embryonic and adult tissues. The majority of studies regarding … new york to melbourneWebGATA3 is one of the three genes mutated in >10% of breast cancers (Cancer Genome Atlas). [29] Studies in mice indicate that the gene is critical for the normal development of … militia power blow mod v4 by ankitWebApr 22, 2014 · The transcription factor GATA3 is a favorable prognostic indicator in estrogen receptor-α (ERα)-positive breast tumors in which it participates with ERα and FOXA1 in a complex transcriptional regulatory program driving tumor growth. GATA3 mutations are frequent in breast cancer and have been classified as driver mutations. To elucidate the … militiaoftheimmaculata.com