How does daptomycin cause myopathy

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August undefined, 2024

WebPatients often have muscle stiffness or weakness. Myositis: This is a type of myopathy that causes inflammation of your muscles, leading to weakness, swelling and pain. Many people with a myopathy, including myositis, manage their symptoms and lead active lives. Medications can often relieve symptoms. WebDaptomycin can cause skeletal muscle myopathy with elevations in CPK. The percentage of patients treated with daptomycin in phase III trials who experienced muscle pain or …

Cardiomyopathy - Symptoms and causes - Mayo Clinic

WebDaptomycin. Daptomycin is a lipopeptide that targets bacterial cell membranes and has been successfully used to treat skin and soft tissue infections caused by Gram-positive bacteria, including E. faecalis species. ... The primary toxicity seen is a dose-dependent, reversible myopathy that can be monitored by elevation in serum creatinine ... WebJan 28, 2024 · new or worsening cough , fever, trouble breathing, unexplained muscle pain, tenderness, and. weakness. Rare side effects of Daptomycin include: none. This is not a … fischers contracting

Muscle pain associated with daptomycin - PubMed

WebDaptomycin is given parenterally once a day. Over 90% is bound to serum protein. Dosing is adjusted for renal failure. Because daptomycin can cause reversible skeletal myopathy, … WebNov 24, 2024 · It is less nephrotoxic than vancomycin. It has a unique bactericidal mechanism through destruction of bacterial membrane potential. However, one of the … WebComment: Coadministration of daptomycin with HMG-CoA reductase inhibitors may increase CPK levels and risk for myopathy; consider temporary suspension of HMG-CoA … camping world akron ohio used rvs

Myopathies: Types, Causes, Diagnosis, and Treatment - WebMD

Rhabdomyolysis during therapy with daptomycin - PubMed

WebMar 1, 2024 · Daptomycin injection is used to treat complicated skin and skin structure infections (cSSSI). It is also used to treat infections in the bloodstream (bacteremia), including right-sided infective endocarditis. Daptomycin belongs to the class of medicines known as antibiotics. It works by killing bacteria or preventing their growth. WebMar 1, 2024 · irregular breathing. irregular heartbeat. irritability. itching in the genital or other skin areas. itching, pain, redness, swelling, tenderness, or warmth on the skin. … fischer scone wagon location in puyallupWebDaptomycin is given parenterally once a day. Over 90% is bound to serum protein. Dosing is adjusted for renal failure. Because daptomycin can cause reversible skeletal myopathy, patients should be monitored for muscle pain or weakness, and serum creatine kinase levels should be checked weekly. NOTE: This is the Professional Version. camping world alvarado

"WebOct 15, 2024 · Background: Daptomycin-associated myopathy has been identified in 2%-14% of patients, and rhabdomyolysis is a known adverse effect. Although risk factors for daptomycin-associated myopathy are poorly defined, creatine phosphokinase (CPK) monitoring and temporary discontinuation of 3-hydroxy-3-methylglutaryl coenzyme A … " - How does daptomycin cause myopathy

How does daptomycin cause myopathy

Daptomycin - Infectious Diseases - MSD Manual Professional Edition

WebDec 19, 2024 · In this retrospective, case-control study, both myopathy and rhabdomyolysis were increased by coadministration. Daptomycin has been associated with clinical myopathy in 2% to 14% of patients. Similarly, statins are associated with myopathy in 5% to 10% of patients. Although prior reports suggested no increased risk for myopathy when … WebNov 24, 2024 · It is less nephrotoxic than vancomycin. It has a unique bactericidal mechanism through destruction of bacterial membrane potential. However, one of the most clinically relevant adverse effects of daptomycin is reversible myopathy, especially when daptomycin is used in high doses.

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WebMar 7, 2024 · dizziness, trouble sleeping (insomnia), anxiety, itching or skin rash, increased sweating, or. injection site reactions (pain, discomfort, irritation, redness, or swelling). Tell your doctor if you have serious side effects of Cubicin including: muscle pain/cramps/weakness, numbness or tingling of hands or feet, WebWhile the statins are effective in providing protection from coronary and cardiovascular events, they are known to cause myopathy (usually dose-related) and, rarely, rhabdomyolysis. 1 A clinical diagnosis of myopathy is made when there is muscle pain or weakness accompanied by a creatine kinase (CK) level more than ten times the upper …

WebJan 1, 2024 · Daptomycin for injection is indicated for the treatment of adult patients with Staphylococcus aureus bloodstream infections (bacteremia), including adult patients with right-sided infective endocarditis, caused by methicillin-susceptible and …

WebClinically relevant plasma concentrations of daptomycin reported to cause a significant concentration-dependent false prolongation of prothrombin time (PT) and elevation of International... WebMar 21, 2024 · Daptomycin may cause a kidney problem called tubulointerstitial nephritis. Check with your doctor right away if you have a bloody or cloudy urine, fever, skin rash, …

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WebNov 23, 2024 · Daptomycin must be mixed with a liquid (diluent) before using it. Prepare your injection only when you are ready to give it. Do not use if the medicine has changed colors or has particles in it. Call your pharmacist for new medicine. You may need frequent blood and urine tests. daptomycin may cause false results with certain medical tests. camping world andersen trailer jack blockWebJun 15, 2006 · The use of daptomycin has been associated with an elevation in creatine phosphokinase level, with a reported incidence of 2.8% in phase III clinical trials. Published case reports have documented the presence of myopathy in patients who received daptomycin; however, there have been no previously reported cases of rhabdomyolysis in … camping world alcoa tnWebConclusion: Daptomycin can be associated with elevations in CPK level and rhabdomyolysis despite reduction of dose. A baseline CPK level before starting … camping world anderson ca inventoryWebDaptomycin injection comes as a powder to be added to fluid and injected into a vein by a doctor or nurse. It is usually given once a day. The length of your treatment depends on … camping world alcoaWebJun 15, 2006 · Given the temporal relationship between daptomycin initiation and elevation in CPK level, daptomycin was identified as the offending agent and was discontinued. … camping world ann arbor michiganWebMar 1, 2024 · Bloating or swelling of the face, arms, hands, lower legs, or feet fever tingling of the hands or feet unusual weight gain or loss Less common Agitation black, tarry stools bladder pain bloody or cloudy urine blurred vision chest pain, discomfort, or tightness chills confusion cough decreased awareness or responsiveness camping world alabama locationsWebMar 21, 2024 · Bloating or swelling of the face, arms, hands, lower legs, or feet fever tingling of the hands or feet unusual weight gain or loss Less common Agitation black, tarry … camping world anderson california accessories