Web18 okt. 2024 · This axon-associated astrocyte population resides in a narrow stratum at the retinal surface, the retinal nerve fiber layer (RNFL), which consists primarily of astrocytes, blood vessels, and the axons of retinal ganglion cells (RGCs; Fig 1A ). We chose these cells for two reasons. Web23 dec. 2024 · Together, our data provide strong evidence that astrocytes eliminate unnecessary excitatory synaptic connections in the adult hippocampus through MEGF10, …
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WebWe found that MEGF10 protein was localized to developing astrocytes visualized by Aldh1l1-EGFP transgene expression 2 in the postnatal day 5 (P5) dorsal lateral … Web24 nov. 2013 · This process helps to mediate synapse elimination, requires the MEGF10 and MERTK phagocytic pathways, and is strongly dependent on neuronal activity. … pappas restaurants in houston
Astrocytes: Heterogeneous and Dynamic Phenotypes in …
WebMEGF10 Antibody (PA5-87956) in WB Western Blot analysis of MEGF10 in extracts of various cell lines using MEGF10 Polyclonal Antibody ( Product # PA5-87956) at a dilution of 1:1000. A HRP Goat Anti-Rabbit IgG (H+L) secondary antibody was used at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Web13 jun. 2024 · Further experiments showed that reducing astrocyte’s ability to respond to Shh impaired synaptic turnover as the brain developed, ... astrocytes directly eliminate synapses in an activity-dependent manner through MEGF10 and MERTK, two phagocytic receptors enriched in astrocytes (Chung et al., 2013). Web7 jul. 2024 · Astrocytes have been shown to express genes enriched in engulfment pathways such as TAM receptors, draper/Megf10, and ABCA1 in gene profiling studies … shari\u0027s restaurant nutrition facts