WebThe current review highlights the challenges that remain in differentiating true disease progression from changes due to radiation therapy, including pseudoprogression and radionecrosis, as well as immune or inflammatory changes that may occur as either an undesired result of cytotoxic therapy or as a desired consequence of immunotherapies. WebMar 15, 2011 · Determining radiographic progression in primary malignant brain tumors has posed a significant challenge to the neuroncology community. Glioblastoma multiforme …

Toxins Free Full-Text Monitoring Radiographic Brain Tumor …

WebDifferentiating posttherapy radiation necrosis from residual/recurrent brain neoplasm is of pivotal importance in managing patients with brain tumors. Pseudoprogression of … Tumor pseudoprogression, also known just as pseudoprogression, corresponds to an increase in lesion size related to treatment, which simulates progressive disease. The term is largely used in brain tumor imaging follow-up, especially for high-grade gliomas (e.g. glioblastoma ), and is observed after combined … See more Due to an overlap between the definitions of pseudoprogression and radiation necrosis, it is not incorrect to say that pseudoprogression represents a mild and self-limiting variant of treatment-related necrosis 1,2. See more It is related to endothelial damage and consequent tissue hypoxia observed after treatment and it has an early occurrence (~60%), usually in the first 3 months after the treatment, but it … See more In almost 60% of cases, pseudoprogression occurs within the first 3 months after completing treatment, but it may occur from the first few weeks to 6 months after … See more Generally patients remain clinically stable without the clinical deterioration usually seen with rapid tumor progression 1. See more data test set

Imaging of tumour response to immunotherapy European …

WebNecrosis is a known late effect of radiation treatment of the brain that can mimic tumor recurrence. It is now appreciated that pseudoprogression, a similar effect, can occur after combined chemoradiotherapy and can occur more quickly and dramatically than after radiation alone. WebApr 20, 2024 · Background: Pseudoprogression (PsP) mimics true early progression (TeP) in conventional imaging, which poses a diagnostic challenge in glioblastoma (GBM) patients who undergo standard concurrent chemoradiation (CCRT). WebApr 4, 2009 · These changes, increasingly known as “pseudoresponses,” can occur immediately after initiating treatment, making accurate assessment of true tumor … marzetti neurochirurgo